Madeira will have the first direct flight from the USA.

Madeira is  gearing up for its first nonstop flights from the U.S - NEW YORK JFK to FUNCHAL.
Azores Airlines will fly weekly this winter between New York JFK and the Madeira capital of Funchal, beginning Nov. 29.

https://www.travelweekly.com/Travel-News/Airline-News/Madeira-getting-its-first-nonstop-flight-from-US

The Madeira autonomous region sits to the southwest of Portugal and to the northwest of Africa. Its primary destinations, which are the island of Madeira itself and nearby Porto Santo, lie approximately 250 miles north of Spain's Canary Islands. While Porto Santo draws tourists for its beaches, visitors make the trek to Madeira to enjoy its mountainous tropical landscape, which rises to more than 6,100 feet above sea level, and for the cultural attractions in Funchal.
Currently, tourists can enter Madeira with proof of vaccination, proof of recent recovery from Covid-19 or proof a negative Covid-19 antigen test result from within 48 hours of boarding their flight.